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UidR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
alcohol D-glucoronoside_Ext glucuronide uidR_mRNA glucopyranuronate uidABC_mRNA UidB UidR uidABC UidA UidC D-glucoronoside uidR


Gensor Unit       
Name: UidR
Description: Molecular biology level
Detailed: UidR negatively regulates the expression of genes required for glucuronoside transport and catabolic process. UidR binds its target sites preventing its own expression and the expression of its regulated genes.
Less detailed: UidR negatively regulates the expression of genes needed for glucuronoside transport and catabolic process.
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0008643 - carbohydrate transport
GO:0019391 - glucuronoside catabolic process
GO:0006811 - ion transport
GO:0008152 - metabolic process
GO:0045892 - negative regulation of transcription, DNA-templated
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cellular_component GO:0009279 - cell outer membrane
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0046930 - pore complex
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0004566 - beta-glucuronidase activity
GO:0016787 - hydrolase activity
GO:0016798 - hydrolase activity, acting on glycosyl bonds
GO:0004553 - hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0042802 - identical protein binding
Read more >
Components:
  Function Name Type
  simple_molecule D-glucoronoside simple_molecule
  simple_molecule D-glucoronoside_Ext simple_molecule
  protein UidA protein
  protein UidB protein
  protein UidC protein
  protein UidR protein
  simple_molecule alcohol simple_molecule
  simple_molecule glucopyranuronate simple_molecule
  simple_molecule glucuronide simple_molecule
  gene uidABC gene
  RNA uidABC_mRNA RNA
  gene uidR gene
  RNA uidR_mRNA RNA


Reactions       
Showing 8 reactions
UidR uidABC uidABC_mRNA
Name: uidABC -> uidABC_mRNA
Description: Transcription of transcription unit uidABC. Reaction inhibition by UidR.
Type: transcription
Pathway Components: uidABC - UidR -> uidABC_mRNA
Components:
Function Name Type
inhibitor UidR protein
reactant uidABC gene
product uidABC_mRNA RNA
UidR uidR uidR_mRNA
Name: uidR -> uidR_mRNA
Description: Transcription of transcription unit uidR. Reaction inhibition by UidR.
Type: transcription
Pathway Components: uidR - UidR -> uidR_mRNA
Components:
Function Name Type
inhibitor UidR protein
reactant uidR gene
product uidR_mRNA RNA
uidR_mRNA UidR
Name: uidR_mRNA -> UidR
Description: Translation of UidR
Type: translation
Pathway Components: uidR_mRNA -> UidR
Components:
Function Name Type
product UidR protein
reactant uidR_mRNA RNA
uidABC_mRNA UidA
Name: uidABC_mRNA -> UidA
Description: Translation of UidA
Type: translation
Pathway Components: uidABC_mRNA -> UidA
Components:
Function Name Type
product UidA protein
reactant uidABC_mRNA RNA
UidA glucuronide glucopyranuronate + alcohol
Name: glucuronide -> glucopyranuronate + alcohol
Description: Reaction transforming glucuronide into glucopyranuronate, alcohol
Type: state transition
Pathway Components: glucuronide - UidA -> glucopyranuronate + alcohol
Components:
Function Name Type
catalyzer UidA protein
product alcohol simple_molecule
product glucopyranuronate simple_molecule
reactant glucuronide simple_molecule
uidABC_mRNA UidB
Name: uidABC_mRNA -> UidB
Description: Translation of UidB
Type: translation
Pathway Components: uidABC_mRNA -> UidB
Components:
Function Name Type
product UidB protein
reactant uidABC_mRNA RNA
UidB D-glucoronoside_Ext D-glucoronoside
Name: D-glucoronoside_Ext -> D-glucoronoside
Description: Transport of D-glucoronoside_Ext through a bacterial membrane, leading to the presence of D-glucoronoside inside the cell.
Type: transport
Pathway Components: D-glucoronoside_Ext - UidB -> D-glucoronoside
Components:
Function Name Type
product D-glucoronoside simple_molecule
reactant D-glucoronoside_Ext simple_molecule
catalyzer UidB protein
uidABC_mRNA UidC
Name: uidABC_mRNA -> UidC
Description: Translation of UidC
Type: translation
Pathway Components: uidABC_mRNA -> UidC
Components:
Function Name Type
product UidC protein
reactant uidABC_mRNA RNA
R1 R2 R3 R4 R5 R6 R7 R8



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