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TrpR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
aroH serine mtr TrpC DAHP erythrose-4P trpR shikimate Mtr aroH_mRNA L-glutamate trpLEDCBA_mRNA indole_Ext 5-P-ribosyl-anthranilate TrpB trpL glutamine TrpA YaiA trpL_mRNA AroM TrpL TrpD chorismate TrpA tryptophan CO2 TrpR shikimate-5-P aroL-yaiA-aroM P-enol-pyruvate TrpE indole-3-glycerol-P glyceraldehyde-P vitamin L1 phosphate TrpD mtr_mRNA pyruvate diphosphate AroH PRPP AroL TrpB aroL-yaiA-aroM_mRNA trpR_mRNA 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P indole TrpR tryptophan trpLEDCBA tryptophan_Ext TrpE chorismate serine


Gensor Unit       
Name: TrpR
Description: Molecular biology level
Detailed: In the presence of tryptophan, TrpR negatively regulates the expression of genes required for tryptophan transport and biosynthetic process. Under these conditions, TrpR is modified to TrpR-tryptophan, binds its target sites preventing its own expression and the expression of its regulated genes. In the absence of effector, TrpR unbinds its target sites enabling the expression of its regulated genes.
Less detailed: In the presence of tryptophan, TrpR negatively regulates the expression of genes needed for tryptophan transport and biosynthetic process.

Physiology level
Detailed: The presence of tryptophan inhibits the expression of genes involved with tryptophan transport and biosynthetic process. Under these conditions the genes necessary for transport and synthesis of tryptophan from serine and conversion of erythrose-4P to chorismate, a precursor of tryptophan, are not expressed.
Less detailed: The presence of tryptophan inhibits the expression of genes needful for transport and synthesis of tryptophan from serine and conversion of erythrose-4P to chorismate, a precursor of tryptophan.
Classification:
Groups: Transcription
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0003333 - amino acid transmembrane transport
GO:0006865 - amino acid transport
GO:0009073 - aromatic amino acid family biosynthetic process
GO:0015801 - aromatic amino acid transport
GO:0009058 - biosynthetic process
GO:0008652 - cellular amino acid biosynthetic process
Read more >
cellular_component GO:0005950 - anthranilate synthase complex
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0005622 - intracellular anatomical structure
GO:0016020 - membrane
Read more >
molecular_function GO:0003849 - 3-deoxy-7-phosphoheptulonate synthase activity
GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0022804 - active transmembrane transporter activity
GO:0004048 - anthranilate phosphoribosyltransferase activity
GO:0004049 - anthranilate synthase activity
Read more >
Components:
  Function Name Type
  simple_molecule 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P simple_molecule
  simple_molecule 5-P-ribosyl-anthranilate simple_molecule
  protein AroH protein
  protein AroL protein
  protein AroM protein
  simple_molecule CO2 simple_molecule
  simple_molecule DAHP simple_molecule
  simple_molecule L-glutamate simple_molecule
  protein Mtr protein
  simple_molecule P-enol-pyruvate simple_molecule
  simple_molecule PRPP simple_molecule
  protein TrpA protein
  complex TrpA-TrpB complex
  protein TrpB protein
  protein TrpC protein
  protein TrpD protein
  protein TrpE protein
  complex TrpE-TrpD complex
  protein TrpL protein
  protein TrpR protein
  complex TrpR-tryptophan complex
  protein YaiA protein
  gene aroH gene
  RNA aroH_mRNA RNA
  gene aroL-yaiA-aroM gene
  RNA aroL-yaiA-aroM_mRNA RNA
  simple_molecule chorismate simple_molecule
  simple_molecule diphosphate simple_molecule
  simple_molecule erythrose-4P simple_molecule
  simple_molecule glutamine simple_molecule
  simple_molecule glyceraldehyde-P simple_molecule
  simple_molecule indole simple_molecule
  simple_molecule indole-3-glycerol-P simple_molecule
  simple_molecule indole_Ext simple_molecule
  gene mtr gene
  RNA mtr_mRNA RNA
  simple_molecule phosphate simple_molecule
  simple_molecule pyruvate simple_molecule
  simple_molecule serine simple_molecule
  simple_molecule shikimate simple_molecule
  simple_molecule shikimate-5-P simple_molecule
  gene trpL gene
  gene trpLEDCBA gene
  RNA trpLEDCBA_mRNA RNA
  RNA trpL_mRNA RNA
  gene trpR gene
  RNA trpR_mRNA RNA
  simple_molecule tryptophan simple_molecule
  simple_molecule tryptophan_Ext simple_molecule
  simple_molecule vitamin L1 simple_molecule


Reactions       
Showing 35 reactions
tryptophan + TrpR TrpR-tryptophan
Name: tryptophan + TrpR -> TrpR-tryptophan
Description: Reaction transforming tryptophan, TrpR into TrpR-tryptophan
Type: state transition
Pathway Components: tryptophan + TrpR -> TrpR-tryptophan
Components:
Function Name Type
reactant TrpR protein
product TrpR-tryptophan complex
reactant tryptophan simple_molecule
TrpR-tryptophan aroH aroH_mRNA
Name: aroH -> aroH_mRNA
Description: Transcription of transcription unit aroH. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: aroH - TrpR-tryptophan -> aroH_mRNA
Components:
Function Name Type
inhibitor TrpR-tryptophan complex
reactant aroH gene
product aroH_mRNA RNA
TrpR-tryptophan aroL-yaiA-aroM aroL-yaiA-aroM_mRNA
Name: aroL-yaiA-aroM -> aroL-yaiA-aroM_mRNA
Description: Transcription of transcription unit aroL-yaiA-aroM. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: aroL-yaiA-aroM - TrpR-tryptophan -> aroL-yaiA-aroM_mRNA
Components:
Function Name Type
inhibitor TrpR-tryptophan complex
reactant aroL-yaiA-aroM gene
product aroL-yaiA-aroM_mRNA RNA
TrpR-tryptophan mtr mtr_mRNA
Name: mtr -> mtr_mRNA
Description: Transcription of transcription unit mtr. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: mtr - TrpR-tryptophan -> mtr_mRNA
Components:
Function Name Type
inhibitor TrpR-tryptophan complex
reactant mtr gene
product mtr_mRNA RNA
TrpR-tryptophan trpL trpL_mRNA
Name: trpL -> trpL_mRNA
Description: Transcription of transcription unit trpL. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: trpL - TrpR-tryptophan -> trpL_mRNA
Components:
Function Name Type
inhibitor TrpR-tryptophan complex
reactant trpL gene
product trpL_mRNA RNA
TrpR-tryptophan trpLEDCBA trpLEDCBA_mRNA
Name: trpLEDCBA -> trpLEDCBA_mRNA
Description: Transcription of transcription unit trpLEDCBA. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: trpLEDCBA - TrpR-tryptophan -> trpLEDCBA_mRNA
Components:
Function Name Type
inhibitor TrpR-tryptophan complex
reactant trpLEDCBA gene
product trpLEDCBA_mRNA RNA
TrpR-tryptophan trpR trpR_mRNA
Name: trpR -> trpR_mRNA
Description: Transcription of transcription unit trpR. Reaction inhibition by TrpR-tryptophan.
Type: transcription
Pathway Components: trpR - TrpR-tryptophan -> trpR_mRNA
Components:
Function Name Type
inhibitor TrpR-tryptophan complex
reactant trpR gene
product trpR_mRNA RNA
mtr_mRNA Mtr
Name: mtr_mRNA -> Mtr
Description: Translation of Mtr
Type: translation
Pathway Components: mtr_mRNA -> Mtr
Components:
Function Name Type
product Mtr protein
reactant mtr_mRNA RNA
Mtr indole_Ext indole
Name: indole_Ext -> indole
Description: Transport of indole_Ext through a bacterial membrane, leading to the presence of indole inside the cell.
Type: transport
Pathway Components: indole_Ext - Mtr -> indole
Components:
Function Name Type
catalyzer Mtr protein
product indole simple_molecule
reactant indole_Ext simple_molecule
Mtr tryptophan_Ext tryptophan
Name: tryptophan_Ext -> tryptophan
Description: Transport of tryptophan_Ext through a bacterial membrane, leading to the presence of tryptophan inside the cell.
Type: transport
Pathway Components: tryptophan_Ext - Mtr -> tryptophan
Components:
Function Name Type
catalyzer Mtr protein
product tryptophan simple_molecule
reactant tryptophan_Ext simple_molecule
aroL-yaiA-aroM_mRNA AroL
Name: aroL-yaiA-aroM_mRNA -> AroL
Description: Translation of AroL
Type: translation
Pathway Components: aroL-yaiA-aroM_mRNA -> AroL
Components:
Function Name Type
product AroL protein
reactant aroL-yaiA-aroM_mRNA RNA
AroL shikimate shikimate-5-P
Name: shikimate -> shikimate-5-P
Description: Reaction transforming shikimate into shikimate-5-P
Type: state transition
Pathway Components: shikimate - AroL -> shikimate-5-P
Components:
Function Name Type
catalyzer AroL protein
reactant shikimate simple_molecule
product shikimate-5-P simple_molecule
aroL-yaiA-aroM_mRNA YaiA
Name: aroL-yaiA-aroM_mRNA -> YaiA
Description: Translation of YaiA
Type: translation
Pathway Components: aroL-yaiA-aroM_mRNA -> YaiA
Components:
Function Name Type
product YaiA protein
reactant aroL-yaiA-aroM_mRNA RNA
aroL-yaiA-aroM_mRNA AroM
Name: aroL-yaiA-aroM_mRNA -> AroM
Description: Translation of AroM
Type: translation
Pathway Components: aroL-yaiA-aroM_mRNA -> AroM
Components:
Function Name Type
product AroM protein
reactant aroL-yaiA-aroM_mRNA RNA
trpL_mRNA TrpL
Name: trpL_mRNA -> TrpL
Description: Translation of TrpL
Type: translation
Pathway Components: trpL_mRNA -> TrpL
Components:
Function Name Type
product TrpL protein
reactant trpL_mRNA RNA
trpR_mRNA TrpR
Name: trpR_mRNA -> TrpR
Description: Translation of TrpR
Type: translation
Pathway Components: trpR_mRNA -> TrpR
Components:
Function Name Type
product TrpR protein
reactant trpR_mRNA RNA
aroH_mRNA AroH
Name: aroH_mRNA -> AroH
Description: Translation of AroH
Type: translation
Pathway Components: aroH_mRNA -> AroH
Components:
Function Name Type
product AroH protein
reactant aroH_mRNA RNA
AroH DAHP tryptophan P-enol-pyruvate + erythrose-4P phosphate + DAHP
Name: P-enol-pyruvate + erythrose-4P -> phosphate + DAHP
Description: Reaction transforming P-enol-pyruvate, erythrose-4P into phosphate, DAHP
Type: state transition
Pathway Components: P-enol-pyruvate + erythrose-4P - AroH - DAHP - tryptophan -> phosphate + DAHP
Components:
Function Name Type
catalyzer AroH protein
inhibitor DAHP simple_molecule
product DAHP simple_molecule
reactant P-enol-pyruvate simple_molecule
reactant erythrose-4P simple_molecule
product phosphate simple_molecule
inhibitor tryptophan simple_molecule
trpLEDCBA_mRNA TrpL
Name: trpLEDCBA_mRNA -> TrpL
Description: Translation of TrpL
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpL
Components:
Function Name Type
product TrpL protein
reactant trpLEDCBA_mRNA RNA
trpLEDCBA_mRNA TrpE
Name: trpLEDCBA_mRNA -> TrpE
Description: Translation of TrpE
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpE
Components:
Function Name Type
product TrpE protein
reactant trpLEDCBA_mRNA RNA
TrpD + TrpE TrpE-TrpD
Name: TrpD + TrpE -> TrpE-TrpD
Description: Reaction transforming TrpD, TrpE into TrpE-TrpD
Type: state transition
Pathway Components: TrpD + TrpE -> TrpE-TrpD
Components:
Function Name Type
reactant TrpD protein
reactant TrpE protein
product TrpE-TrpD complex
TrpE-TrpD tryptophan chorismate + glutamine L-glutamate + vitamin L1 + pyruvate
Name: chorismate + glutamine -> L-glutamate + vitamin L1 + pyruvate
Description: Reaction transforming chorismate, glutamine into L-glutamate, vitamin L1 , pyruvate
Type: state transition
Pathway Components: chorismate + glutamine - TrpE-TrpD - tryptophan -> L-glutamate + vitamin L1 + pyruvate
Components:
Function Name Type
product L-glutamate simple_molecule
catalyzer TrpE-TrpD complex
reactant chorismate simple_molecule
reactant glutamine simple_molecule
product pyruvate simple_molecule
inhibitor tryptophan simple_molecule
product vitamin L1 simple_molecule
trpLEDCBA_mRNA TrpD
Name: trpLEDCBA_mRNA -> TrpD
Description: Translation of TrpD
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpD
Components:
Function Name Type
product TrpD protein
reactant trpLEDCBA_mRNA RNA
TrpD vitamin L1 + PRPP 5-P-ribosyl-anthranilate + diphosphate
Name: vitamin L1 + PRPP -> 5-P-ribosyl-anthranilate + diphosphate
Description: Reaction transforming vitamin L1, PRPP into 5-P-ribosyl-anthranilate, diphosphate
Type: state transition
Pathway Components: vitamin L1 + PRPP - TrpD -> 5-P-ribosyl-anthranilate + diphosphate
Components:
Function Name Type
product 5-P-ribosyl-anthranilate simple_molecule
reactant PRPP simple_molecule
catalyzer TrpD protein
product diphosphate simple_molecule
reactant vitamin L1 simple_molecule
trpLEDCBA_mRNA TrpC
Name: trpLEDCBA_mRNA -> TrpC
Description: Translation of TrpC
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpC
Components:
Function Name Type
product TrpC protein
reactant trpLEDCBA_mRNA RNA
TrpC vitamin L1 Reactants indole-3-glycerol-P + CO2
Name: 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P -> indole-3-glycerol-P + CO2
Description: Reaction transforming 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P into indole-3-glycerol-P, CO2
Type: state transition
Pathway Components: 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P - TrpC - vitamin L1 -> indole-3-glycerol-P + CO2
Components:
Function Name Type
reactant 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P simple_molecule
product CO2 simple_molecule
catalyzer TrpC protein
product indole-3-glycerol-P simple_molecule
inhibitor vitamin L1 simple_molecule
TrpC 5-P-ribosyl-anthranilate Products
Name: 5-P-ribosyl-anthranilate -> 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P
Description: Reaction transforming 5-P-ribosyl-anthranilate into 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P
Type: state transition
Pathway Components: 5-P-ribosyl-anthranilate - TrpC -> 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P
Components:
Function Name Type
product 1-(o-carboxyphenylamino)-1'-deoxyribulose-5'-P simple_molecule
reactant 5-P-ribosyl-anthranilate simple_molecule
catalyzer TrpC protein
trpLEDCBA_mRNA TrpB
Name: trpLEDCBA_mRNA -> TrpB
Description: Translation of TrpB
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpB
Components:
Function Name Type
product TrpB protein
reactant trpLEDCBA_mRNA RNA
TrpA-TrpB TrpB indole + serine tryptophan
Name: indole + serine -> tryptophan
Description: Reaction transforming indole, serine into tryptophan
Type: state transition
Pathway Components: indole + serine - TrpA-TrpB - TrpB -> tryptophan
Components:
Function Name Type
catalyzer TrpA-TrpB complex
catalyzer TrpB protein
reactant indole simple_molecule
reactant serine simple_molecule
product tryptophan simple_molecule
TrpA + TrpB TrpA-TrpB
Name: TrpA + TrpB -> TrpA-TrpB
Description: Reaction transforming TrpA, TrpB into TrpA-TrpB
Type: state transition
Pathway Components: TrpA + TrpB -> TrpA-TrpB
Components:
Function Name Type
reactant TrpA protein
product TrpA-TrpB complex
reactant TrpB protein
TrpA-TrpB indole-3-glycerol-P + serine glyceraldehyde-P + tryptophan
Name: indole-3-glycerol-P + serine -> glyceraldehyde-P + tryptophan
Description: Reaction transforming indole-3-glycerol-P, serine into glyceraldehyde-P, tryptophan
Type: state transition
Pathway Components: indole-3-glycerol-P + serine - TrpA-TrpB -> glyceraldehyde-P + tryptophan
Components:
Function Name Type
catalyzer TrpA-TrpB complex
product glyceraldehyde-P simple_molecule
reactant indole-3-glycerol-P simple_molecule
reactant serine simple_molecule
product tryptophan simple_molecule
TrpA TrpA-TrpB indole-3-glycerol-P glyceraldehyde-P + indole
Name: indole-3-glycerol-P -> glyceraldehyde-P + indole
Description: Reaction transforming indole-3-glycerol-P into glyceraldehyde-P, indole
Type: state transition
Pathway Components: indole-3-glycerol-P - TrpA - TrpA-TrpB -> glyceraldehyde-P + indole
Components:
Function Name Type
catalyzer TrpA protein
catalyzer TrpA-TrpB complex
product glyceraldehyde-P simple_molecule
product indole simple_molecule
reactant indole-3-glycerol-P simple_molecule
trpLEDCBA_mRNA TrpA
Name: trpLEDCBA_mRNA -> TrpA
Description: Translation of TrpA
Type: translation
Pathway Components: trpLEDCBA_mRNA -> TrpA
Components:
Function Name Type
product TrpA protein
reactant trpLEDCBA_mRNA RNA
shikimate-5-P chorismate
Name: shikimate-5-P -> chorismate
Description: Transformation of shikimate-5-P into chorismate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: shikimate-5-P / 2.5.1.19-RXN / CHORISMATE-SYNTHASE-RXN / chorismate
Components:
Function Name Type
product chorismate simple_molecule
reactant shikimate-5-P simple_molecule
DAHP shikimate
Name: DAHP -> shikimate
Description: Transformation of DAHP into shikimate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: DAHP / 3-DEHYDROQUINATE-SYNTHASE-RXN / 3-DEHYDROQUINATE-DEHYDRATASE-RXN / SHIKIMATE-5-DEHYDROGENASE-RXN / shikimate
Components:
Function Name Type
reactant DAHP simple_molecule
product shikimate simple_molecule
R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R11 R12 R13 R14 R15 R16 R17 R18 R19 R20 R21 R22 R23 R24 R25 R26 R27 R28 R29 R30 R31 R32 R33 R34 R35



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