RegulonDB RegulonDB

TreR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
trehalose TreC TreR Crr TreB TreB trehalose_Ext Crr glucose-6-P alpha,alpha-trehalose 6-phosphate glucopyranose HPr - phosphorylated_Ext TreR PtsH treBC alpha,alpha-trehalose 6-phosphate treBC_mRNA TreR trehalose


Gensor Unit       
Name: TreR
Description: Molecular biology level
Detailed: In the absence of trehalose and trehalose-6-phosphate, TreR negatively regulates the expression of genes required for thehalose catabolic process. Under these conditions, TreR remains unmodified, binds its target sites preventing the expression of its regulated genes.
Less detailed: In the absence of trehalose and trehalose-6-phosphate, TreR negatively regulates the expression of genes needed for trehalose catabolism.

Physiology level
Detailed: The presence of trehalose induces the expression involved with trehalose utilization. Under these conditions the genes necessary for transport and conversion of trehalose-6-phosphate to glucose- 6- phosphate are expressed.
Less detailed: The presence of threhalose induces the expression of genes needful for trehalose-6-phosphate transport and conversion to glucose-6-phosphate.
Classification:
Groups: Carbohydrate transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0006974 - cellular response to DNA damage stimulus
GO:0008152 - metabolic process
GO:0009401 - phosphoenolpyruvate-dependent sugar phosphotransferase system
Read more >
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0008788 - alpha,alpha-phosphotrehalase activity
GO:0003824 - catalytic activity
GO:0016787 - hydrolase activity
GO:0016798 - hydrolase activity, acting on glycosyl bonds
GO:0016301 - kinase activity
GO:0008982 - protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO:0090589 - protein-phosphocysteine-trehalose phosphotransferase system transporter activity
Read more >
Components:
  Function Name Type
  simple_molecule α,α-trehalose 6-phosphate simple_molecule
  protein Crr protein
  simple_molecule HPr - phosphorylated_Ext simple_molecule
  simple_molecule PtsH simple_molecule
  protein TreB protein
  complex TreB-Crr complex
  protein TreC protein
  protein TreR protein
  complex TreR-α,α-trehalose 6-phosphate complex
  complex TreR-trehalose complex
  simple_molecule glucopyranose simple_molecule
  simple_molecule glucose-6-P simple_molecule
  gene treBC gene
  RNA treBC_mRNA RNA
  simple_molecule trehalose simple_molecule
  simple_molecule trehalose_Ext simple_molecule


Reactions       
Showing 8 reactions
TreR treBC treBC_mRNA
Name: treBC -> treBC_mRNA
Description: Transcription of transcription unit treBC. Reaction inhibition by TreR.
Type: transcription
Pathway Components: treBC - TreR -> treBC_mRNA
Components:
Function Name Type
inhibitor TreR protein
reactant treBC gene
product treBC_mRNA RNA
α,α-trehalose 6-phosphate + TreR TreR-α,α-trehalose 6-phosphate
Name: α,α-trehalose 6-phosphate + TreR -> TreR-α,α-trehalose 6-phosphate
Description: Reaction transforming α,α-trehalose 6-phosphate, TreR into TreR-α,α-trehalose 6-phosphate
Type: state transition
Pathway Components: α,α-trehalose 6-phosphate + TreR -> TreR-α,α-trehalose 6-phosphate
Components:
Function Name Type
reactant α,α-trehalose 6-phosphate simple_molecule
reactant TreR protein
product TreR-α,α-trehalose 6-phosphate complex
trehalose + TreR TreR-trehalose
Name: trehalose + TreR -> TreR-trehalose
Description: Reaction transforming trehalose, TreR into TreR-trehalose
Type: state transition
Pathway Components: trehalose + TreR -> TreR-trehalose
Components:
Function Name Type
reactant TreR protein
product TreR-trehalose complex
reactant trehalose simple_molecule
treBC_mRNA TreB
Name: treBC_mRNA -> TreB
Description: Translation of TreB
Type: translation
Pathway Components: treBC_mRNA -> TreB
Components:
Function Name Type
product TreB protein
reactant treBC_mRNA RNA
TreB + Crr TreB-Crr
Name: TreB + Crr -> TreB-Crr
Description: Reaction transforming TreB, Crr into TreB-Crr
Type: state transition
Pathway Components: TreB + Crr -> TreB-Crr
Components:
Function Name Type
reactant Crr protein
reactant TreB protein
product TreB-Crr complex
TreB-Crr HPr - phosphorylated_Ext + trehalose_Ext α,α-trehalose 6-phosphate + PtsH
Name: HPr - phosphorylated_Ext + trehalose_Ext -> α,α-trehalose 6-phosphate + PtsH
Description: Transport of HPr - phosphorylated_Ext, trehalose_Ext through a bacterial membrane, leading to the presence of α,α-trehalose 6-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + trehalose_Ext - TreB-Crr -> α,α-trehalose 6-phosphate + PtsH
Components:
Function Name Type
product α,α-trehalose 6-phosphate simple_molecule
reactant HPr - phosphorylated_Ext simple_molecule
product PtsH simple_molecule
catalyzer TreB-Crr complex
reactant trehalose_Ext simple_molecule
treBC_mRNA TreC
Name: treBC_mRNA -> TreC
Description: Translation of TreC
Type: translation
Pathway Components: treBC_mRNA -> TreC
Components:
Function Name Type
product TreC protein
reactant treBC_mRNA RNA
TreC α,α-trehalose 6-phosphate glucopyranose + glucose-6-P
Name: α,α-trehalose 6-phosphate -> glucopyranose + glucose-6-P
Description: Reaction transforming α,α-trehalose 6-phosphate into glucopyranose, glucose-6-P
Type: state transition
Pathway Components: α,α-trehalose 6-phosphate - TreC -> glucopyranose + glucose-6-P
Components:
Function Name Type
reactant α,α-trehalose 6-phosphate simple_molecule
catalyzer TreC protein
product glucopyranose simple_molecule
product glucose-6-P simple_molecule
R1 R2 R3 R4 R5 R6 R7 R8



RegulonDB