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RhaS Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
isodulcit isodulcit lactaldehyde rhaSR rhamnose RhaB rhaBAD_mRNA rhaT rhaT_mRNA rhamnulose-1P rhaSR_mRNA keto-L-rhamnulose RhaA rhamnulofuranose RhaR xylulose RhaS beta-L-lyxose_Ext RhaS RhaT DHAP beta-L-lyxose RhaD rhaBAD rhamnose_Ext beta-L-rhamnopyranose


Gensor Unit       
Name: RhaS
Description: Molecular biology level
Detailed: In the presence of L-rhamnose, RhaS positively regulates the expression of genes required for rhamnose and lyxose transport and catabolic processes and its own expression. Under these conditions, RhaS is modified to RhaS-L-rhamnose, binds its targes sites enabling its own expression and the expression of itrs regulated genes. In the absence of L-rhamnose, RhaS unbinds its target sites preventing the expression of its regulated genes.
Less detailed: In the presence of L-rhamnose, RhaS positively regulates the expression of genes needed for rhamnose and lyxose transport and catabolic processes.

Physiology level
Detailed: The presence of L-rhamnose induces the expression of genes involved with rhamnose and lyxose catabolic processes. Under these conditions, the genes necessary for lyxose isomerization to D-xylulose and conversion of L-rhamnose to dihidroxyacetone-phosphate and L-lactaldehyde are expressed.
Less detailed: The presence of L-rhamnose induces the expression of genes needful for lyxose isomerization to D-xylulose and conversion of L-rhamnose to dihidroxyacetone-phosphate and L-lactaldehyde.
Classification:
Groups: General function prediction only
Carbohydrate transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0019324 - L-lyxose metabolic process
GO:0005975 - carbohydrate metabolic process
GO:0046835 - carbohydrate phosphorylation
GO:0008643 - carbohydrate transport
GO:0008645 - hexose transmembrane transport
GO:0019323 - pentose catabolic process
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
GO:0032991 - protein-containing complex
molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0008740 - L-rhamnose isomerase activity
GO:0042802 - identical protein binding
GO:0016853 - isomerase activity
GO:0016301 - kinase activity
Read more >
Components:
  Function Name Type
  simple_molecule DHAP simple_molecule
  protein RhaA protein
  protein RhaB protein
  protein RhaD protein
  protein RhaR protein
  protein RhaS protein
  complex RhaS-isodulcit complex
  protein RhaT protein
  simple_molecule beta-L-lyxose simple_molecule
  simple_molecule beta-L-lyxose_Ext simple_molecule
  simple_molecule beta-L-rhamnopyranose simple_molecule
  simple_molecule isodulcit simple_molecule
  simple_molecule keto-L-rhamnulose simple_molecule
  simple_molecule lactaldehyde simple_molecule
  gene rhaBAD gene
  RNA rhaBAD_mRNA RNA
  gene rhaSR gene
  RNA rhaSR_mRNA RNA
  gene rhaT gene
  RNA rhaT_mRNA RNA
  simple_molecule rhamnose simple_molecule
  simple_molecule rhamnose_Ext simple_molecule
  simple_molecule rhamnulofuranose simple_molecule
  simple_molecule rhamnulose-1P simple_molecule
  simple_molecule xylulose simple_molecule


Reactions       
Showing 18 reactions
RhaS-isodulcit rhaSR rhaSR_mRNA
Name: rhaSR -> rhaSR_mRNA
Description: Transcription of transcription unit rhaSR. Reaction activation by RhaS-isodulcit, and RhaS.
Type: transcription
Pathway Components: rhaSR - RhaS-isodulcit -> rhaSR_mRNA
Components:
Function Name Type
activator RhaS-isodulcit complex
reactant rhaSR gene
product rhaSR_mRNA RNA
RhaS-isodulcit rhaT rhaT_mRNA
Name: rhaT -> rhaT_mRNA
Description: Transcription of transcription unit rhaT. Reaction activation by RhaS-isodulcit, and RhaS.
Type: transcription
Pathway Components: rhaT - RhaS-isodulcit -> rhaT_mRNA
Components:
Function Name Type
activator RhaS-isodulcit complex
reactant rhaT gene
product rhaT_mRNA RNA
isodulcit + RhaS RhaS-isodulcit
Name: isodulcit + RhaS -> RhaS-isodulcit
Description: Reaction transforming isodulcit, RhaS into RhaS-isodulcit
Type: state transition
Pathway Components: isodulcit + RhaS -> RhaS-isodulcit
Components:
Function Name Type
reactant RhaS protein
product RhaS-isodulcit complex
reactant isodulcit simple_molecule
RhaS-isodulcit rhaBAD rhaBAD_mRNA
Name: rhaBAD -> rhaBAD_mRNA
Description: Transcription of transcription unit rhaBAD. Reaction activation by RhaS-isodulcit.
Type: transcription
Pathway Components: rhaBAD - RhaS-isodulcit -> rhaBAD_mRNA
Components:
Function Name Type
activator RhaS-isodulcit complex
reactant rhaBAD gene
product rhaBAD_mRNA RNA
rhaSR_mRNA RhaS
Name: rhaSR_mRNA -> RhaS
Description: Translation of RhaS
Type: translation
Pathway Components: rhaSR_mRNA -> RhaS
Components:
Function Name Type
product RhaS protein
reactant rhaSR_mRNA RNA
rhaSR_mRNA RhaR
Name: rhaSR_mRNA -> RhaR
Description: Translation of RhaR
Type: translation
Pathway Components: rhaSR_mRNA -> RhaR
Components:
Function Name Type
product RhaR protein
reactant rhaSR_mRNA RNA
rhaBAD_mRNA RhaB
Name: rhaBAD_mRNA -> RhaB
Description: Translation of RhaB
Type: translation
Pathway Components: rhaBAD_mRNA -> RhaB
Components:
Function Name Type
product RhaB protein
reactant rhaBAD_mRNA RNA
RhaB rhamnulofuranose rhamnulose-1P
Name: rhamnulofuranose -> rhamnulose-1P
Description: Reaction transforming rhamnulofuranose into rhamnulose-1P
Type: state transition
Pathway Components: rhamnulofuranose - RhaB -> rhamnulose-1P
Components:
Function Name Type
catalyzer RhaB protein
reactant rhamnulofuranose simple_molecule
product rhamnulose-1P simple_molecule
rhaBAD_mRNA RhaA
Name: rhaBAD_mRNA -> RhaA
Description: Translation of RhaA
Type: translation
Pathway Components: rhaBAD_mRNA -> RhaA
Components:
Function Name Type
product RhaA protein
reactant rhaBAD_mRNA RNA
RhaA beta-L-rhamnopyranose keto-L-rhamnulose
Name: beta-L-rhamnopyranose -> keto-L-rhamnulose
Description: Reaction transforming beta-L-rhamnopyranose into keto-L-rhamnulose
Type: state transition
Pathway Components: beta-L-rhamnopyranose - RhaA -> keto-L-rhamnulose
Components:
Function Name Type
catalyzer RhaA protein
reactant beta-L-rhamnopyranose simple_molecule
product keto-L-rhamnulose simple_molecule
RhaA beta-L-lyxose xylulose
Name: beta-L-lyxose -> xylulose
Description: Reaction transforming beta-L-lyxose into xylulose
Type: state transition
Pathway Components: beta-L-lyxose - RhaA -> xylulose
Components:
Function Name Type
catalyzer RhaA protein
reactant beta-L-lyxose simple_molecule
product xylulose simple_molecule
rhaBAD_mRNA RhaD
Name: rhaBAD_mRNA -> RhaD
Description: Translation of RhaD
Type: translation
Pathway Components: rhaBAD_mRNA -> RhaD
Components:
Function Name Type
product RhaD protein
reactant rhaBAD_mRNA RNA
RhaD rhamnulose-1P lactaldehyde + DHAP
Name: rhamnulose-1P -> lactaldehyde + DHAP
Description: Reaction transforming rhamnulose-1P into lactaldehyde, DHAP
Type: state transition
Pathway Components: rhamnulose-1P - RhaD -> lactaldehyde + DHAP
Components:
Function Name Type
product DHAP simple_molecule
catalyzer RhaD protein
product lactaldehyde simple_molecule
reactant rhamnulose-1P simple_molecule
rhaT_mRNA RhaT
Name: rhaT_mRNA -> RhaT
Description: Translation of RhaT
Type: translation
Pathway Components: rhaT_mRNA -> RhaT
Components:
Function Name Type
product RhaT protein
reactant rhaT_mRNA RNA
RhaT rhamnose_Ext rhamnose
Name: rhamnose_Ext -> rhamnose
Description: Transport of rhamnose_Ext through a bacterial membrane, leading to the presence of rhamnose inside the cell.
Type: transport
Pathway Components: rhamnose_Ext - RhaT -> rhamnose
Components:
Function Name Type
catalyzer RhaT protein
product rhamnose simple_molecule
reactant rhamnose_Ext simple_molecule
RhaT beta-L-lyxose_Ext beta-L-lyxose
Name: beta-L-lyxose_Ext -> beta-L-lyxose
Description: Transport of beta-L-lyxose_Ext through a bacterial membrane, leading to the presence of beta-L-lyxose inside the cell.
Type: transport
Pathway Components: beta-L-lyxose_Ext - RhaT -> beta-L-lyxose
Components:
Function Name Type
catalyzer RhaT protein
product beta-L-lyxose simple_molecule
reactant beta-L-lyxose_Ext simple_molecule
keto-L-rhamnulose rhamnulofuranose
Name: keto-L-rhamnulose -> rhamnulofuranose
Description: Transformation of keto-L-rhamnulose into rhamnulofuranose by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: keto-L-rhamnulose / RXN-15356 / rhamnulofuranose
Components:
Function Name Type
reactant keto-L-rhamnulose simple_molecule
product rhamnulofuranose simple_molecule
isodulcit beta-L-rhamnopyranose
Name: isodulcit -> beta-L-rhamnopyranose
Description: Transformation of isodulcit into beta-L-rhamnopyranose by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: isodulcit / beta-L-rhamnopyranose
Components:
Function Name Type
product beta-L-rhamnopyranose simple_molecule
reactant isodulcit simple_molecule
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