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MelR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
melR melibiose a-methyl-D-galactoside MelR gluconate lithium ion_Ext melibionate_Ext Sodium b-methyl-D-galactoside_Ext melR_mRNA melibiose melAB_mRNA glucopyranose melAB lithium ion b-methyl-D-galactoside alpha-D-galactose MelR melibiose_Ext MelB Sodium_Ext a-methyl-D-galactoside_Ext MelA galactopyranose melibionate MelR MelR melibiose


Gensor Unit       
Name: MelR
Description: Molecular biology level
Detailed: In the presence but also in the absence of melibiose, MelR dually regulates the expression of genes required for methylgalactoside transport and melibiose transport and catabolism. In the presence of melibiose, MelR is modified to MelR-melibiose, binds its target sites enabling or preventing its own expression and the expression of its regulated genes. In the absence of melibiose, MelR can also binds its target sites enabling or preventing its own expression and the expression of its regulated genes.
Less detailed: In the presence but also in the absence of melibiose, MelR dually regulates the expression of genes needed for methyl galactoside transport, and melibiose transport and catabolic process.

Physiology level
Detailed: The presence of melibiose induces in some case and inhibits in others the expression of genes involved with methylgalactoside transport and melibiose transport and catabolism. Under this condition the genes necessary for methylgalactoside and melibiose transport, and for conversion of melibiose to galactose and glucose are in some cases expressed and repressed in other.
Less detailed: The presence of melibiose induce and inhibits the expression of genes needful for methylgalactoside and melibiose transport, and for conversion of melibiose to galactose and glucose
Classification:
Groups: Carbohydrate transport and metabolism
Replication, recombination and repair
Gene Ontology Terms (GO): biological_process GO:0005975 - carbohydrate metabolic process
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0098655 - cation transmembrane transport
GO:0005995 - melibiose catabolic process
GO:0015769 - melibiose transport
Read more >
cellular_component GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0070403 - NAD+ binding
GO:0004557 - alpha-galactosidase activity
GO:0003824 - catalytic activity
GO:0015486 - glycoside-pentoside-hexuronide:cation symporter activity
GO:0016787 - hydrolase activity
Read more >
Components:
  Function Name Type
  simple_molecule α-D-galactose simple_molecule
  protein MelA protein
  protein MelB protein
  protein MelR protein
  complex MelR-melibiose complex
  simple_molecule Sodium simple_molecule
  simple_molecule Sodium_Ext simple_molecule
  simple_molecule a-methyl-D-galactoside simple_molecule
  simple_molecule a-methyl-D-galactoside_Ext simple_molecule
  simple_molecule b-methyl-D-galactoside simple_molecule
  simple_molecule b-methyl-D-galactoside_Ext simple_molecule
  simple_molecule galactopyranose simple_molecule
  simple_molecule gluconate simple_molecule
  simple_molecule glucopyranose simple_molecule
  simple_molecule lithium ion simple_molecule
  simple_molecule lithium ion_Ext simple_molecule
  gene melAB gene
  RNA melAB_mRNA RNA
  gene melR gene
  RNA melR_mRNA RNA
  simple_molecule melibionate simple_molecule
  simple_molecule melibionate_Ext simple_molecule
  simple_molecule melibiose simple_molecule
  simple_molecule melibiose_Ext simple_molecule


Reactions       
Showing 14 reactions
MelR MelR MelR-melibiose MelR-melibiose melAB melAB_mRNA
Name: melAB -> melAB_mRNA
Description: Transcription of transcription unit melAB. Reaction activation by MelR, and MelR-melibiose. Reaction inhibition by MelR, and MelR-melibiose.
Type: transcription
Pathway Components: melAB - MelR - MelR-melibiose - MelR - MelR-melibiose -> melAB_mRNA
Components:
Function Name Type
activator MelR protein
inhibitor MelR protein
activator MelR-melibiose complex
inhibitor MelR-melibiose complex
reactant melAB gene
product melAB_mRNA RNA
MelR MelR-melibiose MelR-melibiose melR melR_mRNA
Name: melR -> melR_mRNA
Description: Transcription of transcription unit melR. Reaction activation by MelR-melibiose. Reaction inhibition by MelR, and MelR-melibiose.
Type: transcription
Pathway Components: melR - MelR - MelR-melibiose - MelR-melibiose -> melR_mRNA
Components:
Function Name Type
inhibitor MelR protein
activator MelR-melibiose complex
inhibitor MelR-melibiose complex
reactant melR gene
product melR_mRNA RNA
melibiose + MelR MelR-melibiose
Name: melibiose + MelR -> MelR-melibiose
Description: Reaction transforming melibiose, MelR into MelR-melibiose
Type: state transition
Pathway Components: melibiose + MelR -> MelR-melibiose
Components:
Function Name Type
reactant MelR protein
product MelR-melibiose complex
reactant melibiose simple_molecule
melR_mRNA MelR
Name: melR_mRNA -> MelR
Description: Translation of MelR
Type: translation
Pathway Components: melR_mRNA -> MelR
Components:
Function Name Type
product MelR protein
reactant melR_mRNA RNA
melAB_mRNA MelA
Name: melAB_mRNA -> MelA
Description: Translation of MelA
Type: translation
Pathway Components: melAB_mRNA -> MelA
Components:
Function Name Type
product MelA protein
reactant melAB_mRNA RNA
MelA melibiose galactopyranose + glucopyranose
Name: melibiose -> galactopyranose + glucopyranose
Description: Reaction transforming melibiose into galactopyranose, glucopyranose
Type: state transition
Pathway Components: melibiose - MelA -> galactopyranose + glucopyranose
Components:
Function Name Type
catalyzer MelA protein
product galactopyranose simple_molecule
product glucopyranose simple_molecule
reactant melibiose simple_molecule
MelA melibionate α-D-galactose + gluconate
Name: melibionate -> α-D-galactose + gluconate
Description: Reaction transforming melibionate into α-D-galactose, gluconate
Type: state transition
Pathway Components: melibionate - MelA -> α-D-galactose + gluconate
Components:
Function Name Type
product α-D-galactose simple_molecule
catalyzer MelA protein
product gluconate simple_molecule
reactant melibionate simple_molecule
melAB_mRNA MelB
Name: melAB_mRNA -> MelB
Description: Translation of MelB
Type: translation
Pathway Components: melAB_mRNA -> MelB
Components:
Function Name Type
product MelB protein
reactant melAB_mRNA RNA
MelB melibiose_Ext melibiose
Name: melibiose_Ext -> melibiose
Description: Transport of melibiose_Ext through a bacterial membrane, leading to the presence of melibiose inside the cell.
Type: transport
Pathway Components: melibiose_Ext - MelB -> melibiose
Components:
Function Name Type
catalyzer MelB protein
product melibiose simple_molecule
reactant melibiose_Ext simple_molecule
MelB melibionate_Ext melibionate
Name: melibionate_Ext -> melibionate
Description: Transport of melibionate_Ext through a bacterial membrane, leading to the presence of melibionate inside the cell.
Type: transport
Pathway Components: melibionate_Ext - MelB -> melibionate
Components:
Function Name Type
catalyzer MelB protein
product melibionate simple_molecule
reactant melibionate_Ext simple_molecule
MelB lithium ion_Ext + melibiose_Ext lithium ion + melibiose
Name: lithium ion_Ext + melibiose_Ext -> lithium ion + melibiose
Description: Transport of lithium ion_Ext, melibiose_Ext through a bacterial membrane, leading to the presence of lithium ion, melibiose inside the cell.
Type: transport
Pathway Components: lithium ion_Ext + melibiose_Ext - MelB -> lithium ion + melibiose
Components:
Function Name Type
catalyzer MelB protein
product lithium ion simple_molecule
reactant lithium ion_Ext simple_molecule
product melibiose simple_molecule
reactant melibiose_Ext simple_molecule
MelB melibiose_Ext + Sodium_Ext melibiose + Sodium
Name: melibiose_Ext + Sodium_Ext -> melibiose + Sodium
Description: Transport of melibiose_Ext, Sodium_Ext through a bacterial membrane, leading to the presence of melibiose, Sodium inside the cell.
Type: transport
Pathway Components: melibiose_Ext + Sodium_Ext - MelB -> melibiose + Sodium
Components:
Function Name Type
catalyzer MelB protein
product Sodium simple_molecule
reactant Sodium_Ext simple_molecule
product melibiose simple_molecule
reactant melibiose_Ext simple_molecule
MelB b-methyl-D-galactoside_Ext + Sodium_Ext b-methyl-D-galactoside + Sodium
Name: b-methyl-D-galactoside_Ext + Sodium_Ext -> b-methyl-D-galactoside + Sodium
Description: Transport of b-methyl-D-galactoside_Ext, Sodium_Ext through a bacterial membrane, leading to the presence of b-methyl-D-galactoside, Sodium inside the cell.
Type: transport
Pathway Components: b-methyl-D-galactoside_Ext + Sodium_Ext - MelB -> b-methyl-D-galactoside + Sodium
Components:
Function Name Type
catalyzer MelB protein
product Sodium simple_molecule
reactant Sodium_Ext simple_molecule
product b-methyl-D-galactoside simple_molecule
reactant b-methyl-D-galactoside_Ext simple_molecule
MelB a-methyl-D-galactoside_Ext a-methyl-D-galactoside
Name: a-methyl-D-galactoside_Ext -> a-methyl-D-galactoside
Description: Transport of a-methyl-D-galactoside_Ext through a bacterial membrane, leading to the presence of a-methyl-D-galactoside inside the cell.
Type: transport
Pathway Components: a-methyl-D-galactoside_Ext - MelB -> a-methyl-D-galactoside
Components:
Function Name Type
catalyzer MelB protein
product a-methyl-D-galactoside simple_molecule
reactant a-methyl-D-galactoside_Ext simple_molecule
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