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GntR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
gntT oxalacetate GntU This Gensor Unit is not yet available GntR 5-ketogluconate gluconate gntT_mRNA glyoxylate gluconate idnK edd-eda_mRNA idonate NfuA CO2 pyruvate IdnT GntR KDGP This Gensor Unit is not yet available idonate_Ext 5-ketogluconate_Ext idnK_mRNA idnDOTR YhgH IdnK gluconate_Ext IdnO This Gensor Unit is not yet available Eda Edd edd-eda This Gensor Unit is not yet available 4-hydroxy-2-oxoglutarate 6-p gluconate IdnD idnDOTR_mRNA IdnR GntK yhgH-nfuA yhgH-nfuA_mRNA GntT glyceraldehyde-P


Gensor Unit       
Name: GntR
Description: Molecular biology level
Detailed: In the absence of gluconate, GntR negatively regulates the expression of genes required for gluconate and idonate transport and catabolic processes. Under these conditions, GntR binds its target sites preventing the expression of its regulated genes. In the presence of gluconate, GntR is modified to GntR-gluconate, unbinds its target sites enabling the expression of its regulated genes.
Less detailed:
Classification:
Groups: General function prediction only
Lipid transport and metabolism
Posttranslational modification, protein turnover, chaperones
Transcription
Carbohydrate transport and metabolism
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0046177 - D-gluconate catabolic process
GO:0019521 - D-gluconate metabolic process
GO:0006308 - DNA catabolic process
GO:0009255 - Entner-Doudoroff pathway through 6-phosphogluconate
GO:0046183 - L-idonate catabolic process
GO:0015726 - L-idonate transmembrane transport
Read more >
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0106009 - (4S)-4-hydroxy-2-oxoglutarate aldolase activity
GO:0008675 - 2-dehydro-3-deoxy-phosphogluconate aldolase activity
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0008700 - 4-hydroxy-2-oxoglutarate aldolase activity
GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0050572 - L-idonate 5-dehydrogenase activity
Read more >
Components:
  Function Name Type
  simple_molecule 4-hydroxy-2-oxoglutarate simple_molecule
  simple_molecule 5-ketogluconate simple_molecule
  simple_molecule 5-ketogluconate_Ext simple_molecule
  simple_molecule 6-p gluconate simple_molecule
  simple_molecule CO2 simple_molecule
  protein Eda protein
  protein Edd protein
  protein GntK protein
  protein GntR protein
  complex GntR-gluconate complex
  protein GntT protein
  protein GntU protein
  protein IdnD protein
  protein IdnK protein
  protein IdnO protein
  protein IdnR protein
  protein IdnT protein
  simple_molecule KDGP simple_molecule
  protein NfuA protein
  protein YhgH protein
  gene edd-eda gene
  RNA edd-eda_mRNA RNA
  simple_molecule gluconate simple_molecule
  simple_molecule gluconate_Ext simple_molecule
  simple_molecule glyceraldehyde-P simple_molecule
  simple_molecule glyoxylate simple_molecule
  gene gntK gene
  gene gntKU gene
  RNA gntKU_mRNA RNA
  RNA gntK_mRNA RNA
  gene gntT gene
  RNA gntT_mRNA RNA
  gene idnDOTR gene
  RNA idnDOTR_mRNA RNA
  gene idnK gene
  RNA idnK_mRNA RNA
  simple_molecule idonate simple_molecule
  simple_molecule idonate_Ext simple_molecule
  simple_molecule oxalacetate simple_molecule
  simple_molecule pyruvate simple_molecule
  gene yhgH-nfuA gene
  RNA yhgH-nfuA_mRNA RNA


Reactions       
Showing 33 reactions
GntR edd-eda edd-eda_mRNA
Name: edd-eda -> edd-eda_mRNA
Description: Transcription of transcription unit edd-eda. Reaction inhibition by GntR.
Type: transcription
Pathway Components: edd-eda - GntR -> edd-eda_mRNA
Components:
Function Name Type
inhibitor GntR protein
reactant edd-eda gene
product edd-eda_mRNA RNA
GntR gntK gntK_mRNA
Name: gntK -> gntK_mRNA
Description: Transcription of transcription unit gntK. Reaction inhibition by GntR.
Type: transcription
Pathway Components: gntK - GntR -> gntK_mRNA
Components:
Function Name Type
inhibitor GntR protein
reactant gntK gene
product gntK_mRNA RNA
GntR gntKU gntKU_mRNA
Name: gntKU -> gntKU_mRNA
Description: Transcription of transcription unit gntKU. Reaction inhibition by GntR.
Type: transcription
Pathway Components: gntKU - GntR -> gntKU_mRNA
Components:
Function Name Type
inhibitor GntR protein
reactant gntKU gene
product gntKU_mRNA RNA
GntR gntT gntT_mRNA
Name: gntT -> gntT_mRNA
Description: Transcription of transcription unit gntT. Reaction inhibition by GntR.
Type: transcription
Pathway Components: gntT - GntR -> gntT_mRNA
Components:
Function Name Type
inhibitor GntR protein
reactant gntT gene
product gntT_mRNA RNA
GntR idnDOTR idnDOTR_mRNA
Name: idnDOTR -> idnDOTR_mRNA
Description: Transcription of transcription unit idnDOTR. Reaction inhibition by GntR.
Type: transcription
Pathway Components: idnDOTR - GntR -> idnDOTR_mRNA
Components:
Function Name Type
inhibitor GntR protein
reactant idnDOTR gene
product idnDOTR_mRNA RNA
GntR idnK idnK_mRNA
Name: idnK -> idnK_mRNA
Description: Transcription of transcription unit idnK. Reaction inhibition by GntR.
Type: transcription
Pathway Components: idnK - GntR -> idnK_mRNA
Components:
Function Name Type
inhibitor GntR protein
reactant idnK gene
product idnK_mRNA RNA
GntR yhgH-nfuA yhgH-nfuA_mRNA
Name: yhgH-nfuA -> yhgH-nfuA_mRNA
Description: Transcription of transcription unit yhgH-nfuA. Reaction inhibition by GntR.
Type: transcription
Pathway Components: yhgH-nfuA - GntR -> yhgH-nfuA_mRNA
Components:
Function Name Type
inhibitor GntR protein
reactant yhgH-nfuA gene
product yhgH-nfuA_mRNA RNA
gluconate + GntR GntR-gluconate
Name: gluconate + GntR -> GntR-gluconate
Description: Reaction transforming gluconate, GntR into GntR-gluconate
Type: state transition
Pathway Components: gluconate + GntR -> GntR-gluconate
Components:
Function Name Type
reactant GntR protein
product GntR-gluconate complex
reactant gluconate simple_molecule
gntKU_mRNA GntK
Name: gntKU_mRNA -> GntK
Description: Translation of GntK
Type: translation
Pathway Components: gntKU_mRNA -> GntK
Components:
Function Name Type
product GntK protein
reactant gntKU_mRNA RNA
GntK IdnK gluconate 6-p gluconate
Name: gluconate -> 6-p gluconate
Description: Reaction transforming gluconate into 6-p gluconate
Type: state transition
Pathway Components: gluconate - GntK - IdnK -> 6-p gluconate
Components:
Function Name Type
product 6-p gluconate simple_molecule
catalyzer GntK protein
catalyzer IdnK protein
reactant gluconate simple_molecule
gntKU_mRNA GntU
Name: gntKU_mRNA -> GntU
Description: Translation of GntU
Type: translation
Pathway Components: gntKU_mRNA -> GntU
Components:
Function Name Type
product GntU protein
reactant gntKU_mRNA RNA
GntT GntU IdnT gluconate_Ext gluconate
Name: gluconate_Ext -> gluconate
Description: Transport of gluconate_Ext through a bacterial membrane, leading to the presence of gluconate inside the cell.
Type: transport
Pathway Components: gluconate_Ext - GntT - GntU - IdnT -> gluconate
Components:
Function Name Type
catalyzer GntT protein
catalyzer GntU protein
catalyzer IdnT protein
product gluconate simple_molecule
reactant gluconate_Ext simple_molecule
gntK_mRNA GntK
Name: gntK_mRNA -> GntK
Description: Translation of GntK
Type: translation
Pathway Components: gntK_mRNA -> GntK
Components:
Function Name Type
product GntK protein
reactant gntK_mRNA RNA
edd-eda_mRNA Edd
Name: edd-eda_mRNA -> Edd
Description: Translation of Edd
Type: translation
Pathway Components: edd-eda_mRNA -> Edd
Components:
Function Name Type
product Edd protein
reactant edd-eda_mRNA RNA
Edd 6-p gluconate KDGP
Name: 6-p gluconate -> KDGP
Description: Reaction transforming 6-p gluconate into KDGP
Type: state transition
Pathway Components: 6-p gluconate - Edd -> KDGP
Components:
Function Name Type
reactant 6-p gluconate simple_molecule
catalyzer Edd protein
product KDGP simple_molecule
edd-eda_mRNA Eda
Name: edd-eda_mRNA -> Eda
Description: Translation of Eda
Type: translation
Pathway Components: edd-eda_mRNA -> Eda
Components:
Function Name Type
product Eda protein
reactant edd-eda_mRNA RNA
6-p gluconate Eda glyceraldehyde-P KDGP glyceraldehyde-P + pyruvate
Name: KDGP -> glyceraldehyde-P + pyruvate
Description: Reaction transforming KDGP into glyceraldehyde-P, pyruvate
Type: state transition
Pathway Components: KDGP - Eda - 6-p gluconate - glyceraldehyde-P -> glyceraldehyde-P + pyruvate
Components:
Function Name Type
inhibitor 6-p gluconate simple_molecule
catalyzer Eda protein
reactant KDGP simple_molecule
inhibitor glyceraldehyde-P simple_molecule
product glyceraldehyde-P simple_molecule
product pyruvate simple_molecule
Eda glyoxylate 4-hydroxy-2-oxoglutarate glyoxylate + pyruvate
Name: 4-hydroxy-2-oxoglutarate -> glyoxylate + pyruvate
Description: Reaction transforming 4-hydroxy-2-oxoglutarate into glyoxylate, pyruvate
Type: state transition
Pathway Components: 4-hydroxy-2-oxoglutarate - Eda - glyoxylate -> glyoxylate + pyruvate
Components:
Function Name Type
reactant 4-hydroxy-2-oxoglutarate simple_molecule
catalyzer Eda protein
inhibitor glyoxylate simple_molecule
product glyoxylate simple_molecule
product pyruvate simple_molecule
Eda oxalacetate pyruvate + CO2
Name: oxalacetate -> pyruvate + CO2
Description: Reaction transforming oxalacetate into pyruvate, CO2
Type: state transition
Pathway Components: oxalacetate - Eda -> pyruvate + CO2
Components:
Function Name Type
product CO2 simple_molecule
catalyzer Eda protein
reactant oxalacetate simple_molecule
product pyruvate simple_molecule
yhgH-nfuA_mRNA YhgH
Name: yhgH-nfuA_mRNA -> YhgH
Description: Translation of YhgH
Type: translation
Pathway Components: yhgH-nfuA_mRNA -> YhgH
Components:
Function Name Type
product YhgH protein
reactant yhgH-nfuA_mRNA RNA
yhgH-nfuA_mRNA NfuA
Name: yhgH-nfuA_mRNA -> NfuA
Description: Translation of NfuA
Type: translation
Pathway Components: yhgH-nfuA_mRNA -> NfuA
Components:
Function Name Type
product NfuA protein
reactant yhgH-nfuA_mRNA RNA
gntT_mRNA GntT
Name: gntT_mRNA -> GntT
Description: Translation of GntT
Type: translation
Pathway Components: gntT_mRNA -> GntT
Components:
Function Name Type
product GntT protein
reactant gntT_mRNA RNA
idnK_mRNA IdnK
Name: idnK_mRNA -> IdnK
Description: Translation of IdnK
Type: translation
Pathway Components: idnK_mRNA -> IdnK
Components:
Function Name Type
product IdnK protein
reactant idnK_mRNA RNA
idnDOTR_mRNA IdnD
Name: idnDOTR_mRNA -> IdnD
Description: Translation of IdnD
Type: translation
Pathway Components: idnDOTR_mRNA -> IdnD
Components:
Function Name Type
product IdnD protein
reactant idnDOTR_mRNA RNA
IdnD idonate 5-ketogluconate
Name: idonate -> 5-ketogluconate
Description: Reaction transforming idonate into 5-ketogluconate
Type: state transition
Pathway Components: idonate - IdnD -> 5-ketogluconate
Components:
Function Name Type
product 5-ketogluconate simple_molecule
catalyzer IdnD protein
reactant idonate simple_molecule
idnDOTR_mRNA IdnO
Name: idnDOTR_mRNA -> IdnO
Description: Translation of IdnO
Type: translation
Pathway Components: idnDOTR_mRNA -> IdnO
Components:
Function Name Type
product IdnO protein
reactant idnDOTR_mRNA RNA
IdnO gluconate 5-ketogluconate
Name: gluconate -> 5-ketogluconate
Description: Reaction transforming gluconate into 5-ketogluconate
Type: state transition
Pathway Components: gluconate - IdnO -> 5-ketogluconate
Components:
Function Name Type
product 5-ketogluconate simple_molecule
catalyzer IdnO protein
reactant gluconate simple_molecule
idnDOTR_mRNA IdnT
Name: idnDOTR_mRNA -> IdnT
Description: Translation of IdnT
Type: translation
Pathway Components: idnDOTR_mRNA -> IdnT
Components:
Function Name Type
product IdnT protein
reactant idnDOTR_mRNA RNA
IdnT 5-ketogluconate_Ext 5-ketogluconate
Name: 5-ketogluconate_Ext -> 5-ketogluconate
Description: Transport of 5-ketogluconate_Ext through a bacterial membrane, leading to the presence of 5-ketogluconate inside the cell.
Type: transport
Pathway Components: 5-ketogluconate_Ext - IdnT -> 5-ketogluconate
Components:
Function Name Type
product 5-ketogluconate simple_molecule
reactant 5-ketogluconate_Ext simple_molecule
catalyzer IdnT protein
IdnT idonate_Ext idonate
Name: idonate_Ext -> idonate
Description: Transport of idonate_Ext through a bacterial membrane, leading to the presence of idonate inside the cell.
Type: transport
Pathway Components: idonate_Ext - IdnT -> idonate
Components:
Function Name Type
catalyzer IdnT protein
product idonate simple_molecule
reactant idonate_Ext simple_molecule
idnDOTR_mRNA IdnR
Name: idnDOTR_mRNA -> IdnR
Description: Translation of IdnR
Type: translation
Pathway Components: idnDOTR_mRNA -> IdnR
Components:
Function Name Type
product IdnR protein
reactant idnDOTR_mRNA RNA
5-ketogluconate gluconate
Name: 5-ketogluconate -> gluconate
Description: Transformation of 5-ketogluconate into gluconate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: 5-ketogluconate / 1.1.1.215-RXN / gluconate
Components:
Function Name Type
reactant 5-ketogluconate simple_molecule
product gluconate simple_molecule
5-ketogluconate gluconate
Name: 5-ketogluconate -> gluconate
Description: Transformation of 5-ketogluconate into gluconate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: 5-ketogluconate / gluconate
Components:
Function Name Type
reactant 5-ketogluconate simple_molecule
product gluconate simple_molecule
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