RegulonDB RegulonDB

GcvA Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
methylene-H4PteGlu(n) GcvP CO2 GcvT glycine GcvA Lpd gcvA_mRNA RNA:GcvB GcvA purine gcvB_mRNA GcvT [glycine-cleavage complex H protein] N6-lipoyl-L-lysine purine GcvA THF polyglutamate Lpd gcvA gcvB GcvH [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine ammonium [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine GcvH GcvP gcvTHP_mRNA glycine gcvTHP glycine


Gensor Unit       
Name: GcvA
Description: Molecular biology level
Detailed: In the absence of glycine and purine, GcvA negatively regulates its own expression, dually regulates the expression of genes required for glycine decarboxylation via glycine cleavage system and negatively regulates the expression of a small regulatory RNA. Under these conditions, GcvA remains unmodified, binds its target sites preventing its own expression, enabling the expression of a small regulatory RNA, and alternatively preventing and enabling the expression of other of its regulated genes.
Less detailed: In the absence of glycine and purine GcvA negatively regulates its own expression, positively regulates the expression of a small regulatory RNA, and dually regulates the expression of genes needed for glycine decarboxylation via glycine cleavage system.

Physiology level
Detailed: The presence of glycine and purine alternatively induces and inhibits the expression of genes involved with glycine decarboxylation via glycine cleavage system. Under these conditions the genes necessary for glycine decarboxylation through the H protein complex with release of CO2 and ammonia are dually expressed.
Less detailed: The presence of glycine and purine alternatively induces and inhibits the expression of genes needful for glycine decarboxylation through the H protein complex with release of CO2 and ammonia.
Classification:
Groups: Transcription
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0009257 - 10-formyltetrahydrofolate biosynthetic process
GO:0040033 - RNA-mediated gene silencing by inhibition of translation
GO:0006546 - glycine catabolic process
GO:0019464 - glycine decarboxylation via glycine cleavage system
GO:0006544 - glycine metabolic process
GO:0032259 - methylation
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005960 - glycine cleavage complex
molecular_function GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0004047 - aminomethyltransferase activity
GO:0003824 - catalytic activity
GO:0004375 - glycine dehydrogenase (decarboxylating) activity
GO:0042802 - identical protein binding
GO:0031405 - lipoic acid binding
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Components:
  Function Name Type
  simple_molecule CO2 simple_molecule
  protein GcvA protein
  complex GcvA-glycine complex
  complex GcvA-purine complex
  protein GcvH protein
  protein GcvP protein
  protein GcvT protein
  protein Lpd protein
  complex Lpd-GcvP-GcvH-GcvT complex
  protein RNA:GcvB protein
  simple_molecule THF polyglutamate simple_molecule
  simple_molecule [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine simple_molecule
  simple_molecule [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine simple_molecule
  simple_molecule [glycine-cleavage complex H protein] N6-lipoyl-L-lysine simple_molecule
  simple_molecule ammonium simple_molecule
  gene gcvA gene
  RNA gcvA_mRNA RNA
  gene gcvB gene
  RNA gcvB_mRNA RNA
  gene gcvTHP gene
  RNA gcvTHP_mRNA RNA
  simple_molecule glycine simple_molecule
  simple_molecule methylene-H4PteGlu(n) simple_molecule
  simple_molecule purine simple_molecule


Reactions       
Showing 16 reactions
GcvA gcvB gcvB_mRNA
Name: gcvB -> gcvB_mRNA
Description: Transcription of transcription unit gcvB. Reaction activation by GcvA.
Type: transcription
Pathway Components: gcvB - GcvA -> gcvB_mRNA
Components:
Function Name Type
activator GcvA protein
reactant gcvB gene
product gcvB_mRNA RNA
GcvA GcvA gcvTHP gcvTHP_mRNA
Name: gcvTHP -> gcvTHP_mRNA
Description: Transcription of transcription unit gcvTHP. Reaction activation by GcvA. Reaction inhibition by GcvA.
Type: transcription
Pathway Components: gcvTHP - GcvA - GcvA -> gcvTHP_mRNA
Components:
Function Name Type
activator GcvA protein
inhibitor GcvA protein
reactant gcvTHP gene
product gcvTHP_mRNA RNA
GcvA gcvA gcvA_mRNA
Name: gcvA -> gcvA_mRNA
Description: Transcription of transcription unit gcvA. Reaction inhibition by GcvA.
Type: transcription
Pathway Components: gcvA - GcvA -> gcvA_mRNA
Components:
Function Name Type
inhibitor GcvA protein
reactant gcvA gene
product gcvA_mRNA RNA
purine + GcvA GcvA-purine
Name: purine + GcvA -> GcvA-purine
Description: Reaction transforming purine, GcvA into GcvA-purine
Type: state transition
Pathway Components: purine + GcvA -> GcvA-purine
Components:
Function Name Type
reactant GcvA protein
product GcvA-purine complex
reactant purine simple_molecule
glycine + GcvA GcvA-glycine
Name: glycine + GcvA -> GcvA-glycine
Description: Reaction transforming glycine, GcvA into GcvA-glycine
Type: state transition
Pathway Components: glycine + GcvA -> GcvA-glycine
Components:
Function Name Type
reactant GcvA protein
product GcvA-glycine complex
reactant glycine simple_molecule
gcvTHP_mRNA GcvT
Name: gcvTHP_mRNA -> GcvT
Description: Translation of GcvT
Type: translation
Pathway Components: gcvTHP_mRNA -> GcvT
Components:
Function Name Type
product GcvT protein
reactant gcvTHP_mRNA RNA
GcvT + GcvP + GcvH + Lpd Lpd-GcvP-GcvH-GcvT
Name: GcvT + GcvP + GcvH + Lpd -> Lpd-GcvP-GcvH-GcvT
Description: Reaction transforming GcvT, GcvP, GcvH, Lpd into Lpd-GcvP-GcvH-GcvT
Type: state transition
Pathway Components: GcvT + GcvP + GcvH + Lpd -> Lpd-GcvP-GcvH-GcvT
Components:
Function Name Type
reactant GcvH protein
reactant GcvP protein
reactant GcvT protein
reactant Lpd protein
product Lpd-GcvP-GcvH-GcvT complex
Lpd-GcvP-GcvH-GcvT THF polyglutamate + glycine methylene-H4PteGlu(n) + ammonium + CO2
Name: THF polyglutamate + glycine -> methylene-H4PteGlu(n) + ammonium + CO2
Description: Reaction transforming THF polyglutamate, glycine into methylene-H4PteGlu(n), ammonium , CO2
Type: state transition
Pathway Components: THF polyglutamate + glycine - Lpd-GcvP-GcvH-GcvT -> methylene-H4PteGlu(n) + ammonium + CO2
Components:
Function Name Type
product CO2 simple_molecule
catalyzer Lpd-GcvP-GcvH-GcvT complex
reactant THF polyglutamate simple_molecule
product ammonium simple_molecule
reactant glycine simple_molecule
product methylene-H4PteGlu(n) simple_molecule
GcvP Lpd-GcvP-GcvH-GcvT Reactants Products
Name: [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + glycine -> [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + CO2
Description: Reaction transforming [glycine-cleavage complex H protein] N6-lipoyl-L-lysine, glycine into [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine, CO2
Type: state transition
Pathway Components: [glycine-cleavage complex H protein] N6-lipoyl-L-lysine + glycine - GcvP - Lpd-GcvP-GcvH-GcvT -> [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + CO2
Components:
Function Name Type
product CO2 simple_molecule
catalyzer GcvP protein
catalyzer Lpd-GcvP-GcvH-GcvT complex
product [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine simple_molecule
reactant [glycine-cleavage complex H protein] N6-lipoyl-L-lysine simple_molecule
reactant glycine simple_molecule
GcvT Lpd-GcvP-GcvH-GcvT Reactants Products
Name: [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + THF polyglutamate -> [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + methylene-H4PteGlu(n) + ammonium
Description: Reaction transforming [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine, THF polyglutamate into [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine, methylene-H4PteGlu(n) , ammonium
Type: state transition
Pathway Components: [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine + THF polyglutamate - GcvT - Lpd-GcvP-GcvH-GcvT -> [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine + methylene-H4PteGlu(n) + ammonium
Components:
Function Name Type
catalyzer GcvT protein
catalyzer Lpd-GcvP-GcvH-GcvT complex
reactant THF polyglutamate simple_molecule
reactant [glycine-cleavage complex H protein] N6-aminomethyldihydrolipoyl-L-lysine simple_molecule
product [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine simple_molecule
product ammonium simple_molecule
product methylene-H4PteGlu(n) simple_molecule
Lpd-GcvP-GcvH-GcvT Reactants Products
Name: [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine -> [glycine-cleavage complex H protein] N6-lipoyl-L-lysine
Description: Reaction transforming [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine into [glycine-cleavage complex H protein] N6-lipoyl-L-lysine
Type: state transition
Pathway Components: [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine - Lpd-GcvP-GcvH-GcvT -> [glycine-cleavage complex H protein] N6-lipoyl-L-lysine
Components:
Function Name Type
catalyzer Lpd-GcvP-GcvH-GcvT complex
reactant [glycine-cleavage complex H protein] N6-dihydrolipoyl-L-lysine simple_molecule
product [glycine-cleavage complex H protein] N6-lipoyl-L-lysine simple_molecule
gcvTHP_mRNA GcvH
Name: gcvTHP_mRNA -> GcvH
Description: Translation of GcvH
Type: translation
Pathway Components: gcvTHP_mRNA -> GcvH
Components:
Function Name Type
product GcvH protein
reactant gcvTHP_mRNA RNA
gcvTHP_mRNA GcvP
Name: gcvTHP_mRNA -> GcvP
Description: Translation of GcvP
Type: translation
Pathway Components: gcvTHP_mRNA -> GcvP
Components:
Function Name Type
product GcvP protein
reactant gcvTHP_mRNA RNA
gcvA_mRNA GcvA
Name: gcvA_mRNA -> GcvA
Description: Translation of GcvA
Type: translation
Pathway Components: gcvA_mRNA -> GcvA
Components:
Function Name Type
product GcvA protein
reactant gcvA_mRNA RNA
gcvB_mRNA RNA:GcvB
Name: gcvB_mRNA -> RNA:GcvB
Description: Translation of RNA:GcvB
Type: translation
Pathway Components: gcvB_mRNA -> RNA:GcvB
Components:
Function Name Type
product RNA:GcvB protein
reactant gcvB_mRNA RNA
methylene-H4PteGlu(n) glycine
Name: methylene-H4PteGlu(n) -> glycine
Description: Transformation of methylene-H4PteGlu(n) into glycine by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: methylene-H4PteGlu(n) / glycine
Components:
Function Name Type
product glycine simple_molecule
reactant methylene-H4PteGlu(n) simple_molecule
R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R11 R12 R13 R14 R15 R16



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