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GatR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
DHAP GatA dulcite_Ext GatC sorbitol 6-phosphate GatB galactitol 1-phosphate GatC GatD gatYZABCD glyceraldehyde-P PtsH keto-D-tagatose 6-phosphate gulitol_Ext tagatofuranose 1,6-diphosphate GatB GatR gatYZABCD_mRNA Hpr-Histidine GatZ GatY GatZ GatA GatY Hpr-pi-phospho-L-histidines_Ext HPr - phosphorylated_Ext


Gensor Unit       
Name: GatR
Description: Molecular biology level
Detailed: GatR negatively regulates the expression of genes required for galactitol transport and catbolic process. GatR binds its target sites and prevents the expression of its regulated genes.
Less detailed: GatR negatively regulates the expression of genes needed for galactitol transport and catabolica processes.

Physiology level
Detailed: GatR inhibits the expression of genes involved with galactitol transport and catabolic process, the genes necessary for transport and conversion of galactitol to D-glyceraldehyde-3-phosphate and dihidroxyacetone phosphate are not expressed.
Less detailed: GatR inhibits the expression of genes needful for import of galactitol and its transformation to Glycerladehyde-3-phosphate and dihydroxyacetone phosphate.
Classification:
Groups: Carbohydrate transport and metabolism
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:2001059 - D-tagatose 6-phosphate catabolic process
GO:0005975 - carbohydrate metabolic process
GO:0034219 - carbohydrate transmembrane transport
GO:0008643 - carbohydrate transport
GO:0019404 - galactitol catabolic process
GO:0019402 - galactitol metabolic process
Read more >
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0016832 - aldehyde-lyase activity
GO:0003824 - catalytic activity
GO:0015577 - galactitol transmembrane transporter activity
GO:0008868 - galactitol-1-phosphate 5-dehydrogenase activity
GO:0042802 - identical protein binding
GO:0016301 - kinase activity
GO:0016829 - lyase activity
Read more >
Components:
  Function Name Type
  simple_molecule DHAP simple_molecule
  protein GatA protein
  protein GatB protein
  protein GatC protein
  complex GatC-GatB-GatA complex
  protein GatD protein
  protein GatR protein
  protein GatY protein
  complex GatY-GatZ complex
  protein GatZ protein
  simple_molecule HPr - phosphorylated_Ext simple_molecule
  simple_molecule Hpr-Histidine simple_molecule
  simple_molecule Hpr-pi-phospho-L-histidines_Ext simple_molecule
  simple_molecule PtsH simple_molecule
  simple_molecule dulcite_Ext simple_molecule
  simple_molecule galactitol 1-phosphate simple_molecule
  gene gatYZABCD gene
  RNA gatYZABCD_mRNA RNA
  simple_molecule glyceraldehyde-P simple_molecule
  simple_molecule gulitol_Ext simple_molecule
  simple_molecule keto-D-tagatose 6-phosphate simple_molecule
  simple_molecule sorbitol 6-phosphate simple_molecule
  simple_molecule tagatofuranose 1,6-diphosphate simple_molecule


Reactions       
Showing 14 reactions
GatR gatYZABCD gatYZABCD_mRNA
Name: gatYZABCD -> gatYZABCD_mRNA
Description: Transcription of transcription unit gatYZABCD. Reaction inhibition by GatR.
Type: transcription
Pathway Components: gatYZABCD - GatR -> gatYZABCD_mRNA
Components:
Function Name Type
inhibitor GatR protein
reactant gatYZABCD gene
product gatYZABCD_mRNA RNA
gatYZABCD_mRNA GatY
Name: gatYZABCD_mRNA -> GatY
Description: Translation of GatY
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatY
Components:
Function Name Type
product GatY protein
reactant gatYZABCD_mRNA RNA
GatZ + GatY GatY-GatZ
Name: GatZ + GatY -> GatY-GatZ
Description: Reaction transforming GatZ, GatY into GatY-GatZ
Type: state transition
Pathway Components: GatZ + GatY -> GatY-GatZ
Components:
Function Name Type
reactant GatY protein
product GatY-GatZ complex
reactant GatZ protein
GatY-GatZ tagatofuranose 1,6-diphosphate glyceraldehyde-P + DHAP
Name: tagatofuranose 1,6-diphosphate -> glyceraldehyde-P + DHAP
Description: Reaction transforming tagatofuranose 1,6-diphosphate into glyceraldehyde-P, DHAP
Type: state transition
Pathway Components: tagatofuranose 1,6-diphosphate - GatY-GatZ -> glyceraldehyde-P + DHAP
Components:
Function Name Type
product DHAP simple_molecule
catalyzer GatY-GatZ complex
product glyceraldehyde-P simple_molecule
reactant tagatofuranose 1,6-diphosphate simple_molecule
gatYZABCD_mRNA GatZ
Name: gatYZABCD_mRNA -> GatZ
Description: Translation of GatZ
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatZ
Components:
Function Name Type
product GatZ protein
reactant gatYZABCD_mRNA RNA
gatYZABCD_mRNA GatA
Name: gatYZABCD_mRNA -> GatA
Description: Translation of GatA
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatA
Components:
Function Name Type
product GatA protein
reactant gatYZABCD_mRNA RNA
GatA + GatC + GatB GatC-GatB-GatA
Name: GatA + GatC + GatB -> GatC-GatB-GatA
Description: Reaction transforming GatA, GatC, GatB into GatC-GatB-GatA
Type: state transition
Pathway Components: GatA + GatC + GatB -> GatC-GatB-GatA
Components:
Function Name Type
reactant GatA protein
reactant GatB protein
reactant GatC protein
product GatC-GatB-GatA complex
GatC-GatB-GatA Hpr-pi-phospho-L-histidines_Ext + dulcite_Ext galactitol 1-phosphate + Hpr-Histidine
Name: Hpr-pi-phospho-L-histidines_Ext + dulcite_Ext -> galactitol 1-phosphate + Hpr-Histidine
Description: Transport of Hpr-pi-phospho-L-histidines_Ext, dulcite_Ext through a bacterial membrane, leading to the presence of galactitol 1-phosphate, Hpr-Histidine inside the cell.
Type: transport
Pathway Components: Hpr-pi-phospho-L-histidines_Ext + dulcite_Ext - GatC-GatB-GatA -> galactitol 1-phosphate + Hpr-Histidine
Components:
Function Name Type
catalyzer GatC-GatB-GatA complex
product Hpr-Histidine simple_molecule
reactant Hpr-pi-phospho-L-histidines_Ext simple_molecule
reactant dulcite_Ext simple_molecule
product galactitol 1-phosphate simple_molecule
GatC-GatB-GatA HPr - phosphorylated_Ext + gulitol_Ext sorbitol 6-phosphate + PtsH
Name: HPr - phosphorylated_Ext + gulitol_Ext -> sorbitol 6-phosphate + PtsH
Description: Transport of HPr - phosphorylated_Ext, gulitol_Ext through a bacterial membrane, leading to the presence of sorbitol 6-phosphate, PtsH inside the cell.
Type: transport
Pathway Components: HPr - phosphorylated_Ext + gulitol_Ext - GatC-GatB-GatA -> sorbitol 6-phosphate + PtsH
Components:
Function Name Type
catalyzer GatC-GatB-GatA complex
reactant HPr - phosphorylated_Ext simple_molecule
product PtsH simple_molecule
reactant gulitol_Ext simple_molecule
product sorbitol 6-phosphate simple_molecule
gatYZABCD_mRNA GatB
Name: gatYZABCD_mRNA -> GatB
Description: Translation of GatB
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatB
Components:
Function Name Type
product GatB protein
reactant gatYZABCD_mRNA RNA
gatYZABCD_mRNA GatC
Name: gatYZABCD_mRNA -> GatC
Description: Translation of GatC
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatC
Components:
Function Name Type
product GatC protein
reactant gatYZABCD_mRNA RNA
gatYZABCD_mRNA GatD
Name: gatYZABCD_mRNA -> GatD
Description: Translation of GatD
Type: translation
Pathway Components: gatYZABCD_mRNA -> GatD
Components:
Function Name Type
product GatD protein
reactant gatYZABCD_mRNA RNA
GatD galactitol 1-phosphate keto-D-tagatose 6-phosphate
Name: galactitol 1-phosphate -> keto-D-tagatose 6-phosphate
Description: Reaction transforming galactitol 1-phosphate into keto-D-tagatose 6-phosphate
Type: state transition
Pathway Components: galactitol 1-phosphate - GatD -> keto-D-tagatose 6-phosphate
Components:
Function Name Type
catalyzer GatD protein
reactant galactitol 1-phosphate simple_molecule
product keto-D-tagatose 6-phosphate simple_molecule
keto-D-tagatose 6-phosphate tagatofuranose 1,6-diphosphate
Name: keto-D-tagatose 6-phosphate -> tagatofuranose 1,6-diphosphate
Description: Transformation of keto-D-tagatose 6-phosphate into tagatofuranose 1,6-diphosphate by one or more reactions not shown.
Type: complementary pathway reaction
Pathway Components: keto-D-tagatose 6-phosphate / RXN-16992 / TAGAKIN-RXN / tagatofuranose 1,6-diphosphate
Components:
Function Name Type
reactant keto-D-tagatose 6-phosphate simple_molecule
product tagatofuranose 1,6-diphosphate simple_molecule
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