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FucR Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
fuculose-1-P fucPIKUR_mRNA glycol FucR FucU FucO arabinose_Ext lactaldehyde glycoaldehyde fucose_Ext FucK arabinopyranose galactose_Ext fucose fuculose-1-P galactose FucR FucI arabinose DHAP ribulose alpha-L-fucose fuculose fucAO_mRNA beta-L-fucose fucAO fucPIKUR 1,2-propanediol FucA ribulose-1-P FucP fuculose-1-P


Gensor Unit       
Name: FucR
Description: Molecular biology level
Detailed: In the presence of L-fuculose-1-phosphate, FucR positively regulates the expression of genes required for fucose transport and catabolic processes. Under these condition, FucR is modified to FucR-L-fuculose-1-phosphate, binds its target sites enabling the expression of its regulated genes. In the absence of L-fuculose-1-phosphate, FucR unbinds its target sites preventing the expression of its regulated genes.
Less detailed: In the presence of L-fuculose-1-phosphate, FucR positively regulates the expression of genes needed for fucose transport and catabolic processes.

Physiology level
Detailed: The presence of L-fuculose-1-phosphate induces the expression of genes involved with fucose transport and catabolism. Under this conditions, the genes necessary for fucose transport and degradation to L-lactaldehyde and glycerone phosphate (that feeds glycolysis), are expressed.
Less detailed: The presence of L-fuculose-1-phosphate induces the expression of genes needful for transport of fucose and its degradation to L-lactaldehyde and glycerone phosphate.
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Energy production and conversion
Gene Ontology Terms (GO): biological_process GO:0019571 - D-arabinose catabolic process
GO:0042355 - L-fucose catabolic process
GO:0042354 - L-fucose metabolic process
GO:0015751 - arabinose transmembrane transport
GO:0005975 - carbohydrate metabolic process
GO:0046835 - carbohydrate phosphorylation
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cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005622 - intracellular anatomical structure
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0005524 - ATP binding
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0008736 - L-fucose isomerase activity
GO:0008737 - L-fuculokinase activity
GO:0008738 - L-fuculose-phosphate aldolase activity
GO:0004022 - alcohol dehydrogenase (NAD+) activity
Read more >
Components:
  Function Name Type
  simple_molecule α-L-fucose simple_molecule
  simple_molecule 1,2-propanediol simple_molecule
  simple_molecule DHAP simple_molecule
  protein FucA protein
  protein FucI protein
  protein FucK protein
  protein FucO protein
  protein FucP protein
  protein FucR protein
  complex FucR-fuculose-1-P complex
  protein FucU protein
  simple_molecule arabinopyranose simple_molecule
  simple_molecule arabinose simple_molecule
  simple_molecule arabinose_Ext simple_molecule
  simple_molecule beta-L-fucose simple_molecule
  gene fucAO gene
  RNA fucAO_mRNA RNA
  gene fucPIKUR gene
  RNA fucPIKUR_mRNA RNA
  simple_molecule fucose simple_molecule
  simple_molecule fucose_Ext simple_molecule
  simple_molecule fuculose simple_molecule
  simple_molecule fuculose-1-P simple_molecule
  simple_molecule galactose simple_molecule
  simple_molecule galactose_Ext simple_molecule
  simple_molecule glycoaldehyde simple_molecule
  simple_molecule glycol simple_molecule
  simple_molecule lactaldehyde simple_molecule
  simple_molecule ribulose simple_molecule
  simple_molecule ribulose-1-P simple_molecule


Reactions       
Showing 22 reactions
fuculose-1-P + FucR FucR-fuculose-1-P
Name: fuculose-1-P + FucR -> FucR-fuculose-1-P
Description: Reaction transforming fuculose-1-P, FucR into FucR-fuculose-1-P
Type: state transition
Pathway Components: fuculose-1-P + FucR -> FucR-fuculose-1-P
Components:
Function Name Type
reactant FucR protein
product FucR-fuculose-1-P complex
reactant fuculose-1-P simple_molecule
FucR-fuculose-1-P fucAO fucAO_mRNA
Name: fucAO -> fucAO_mRNA
Description: Transcription of transcription unit fucAO. Reaction activation by FucR-fuculose-1-P.
Type: transcription
Pathway Components: fucAO - FucR-fuculose-1-P -> fucAO_mRNA
Components:
Function Name Type
activator FucR-fuculose-1-P complex
reactant fucAO gene
product fucAO_mRNA RNA
FucR-fuculose-1-P fucPIKUR fucPIKUR_mRNA
Name: fucPIKUR -> fucPIKUR_mRNA
Description: Transcription of transcription unit fucPIKUR. Reaction activation by FucR-fuculose-1-P.
Type: transcription
Pathway Components: fucPIKUR - FucR-fuculose-1-P -> fucPIKUR_mRNA
Components:
Function Name Type
activator FucR-fuculose-1-P complex
reactant fucPIKUR gene
product fucPIKUR_mRNA RNA
fucPIKUR_mRNA FucP
Name: fucPIKUR_mRNA -> FucP
Description: Translation of FucP
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucP
Components:
Function Name Type
product FucP protein
reactant fucPIKUR_mRNA RNA
FucP fucose_Ext fucose
Name: fucose_Ext -> fucose
Description: Transport of fucose_Ext through a bacterial membrane, leading to the presence of fucose inside the cell.
Type: transport
Pathway Components: fucose_Ext - FucP -> fucose
Components:
Function Name Type
catalyzer FucP protein
product fucose simple_molecule
reactant fucose_Ext simple_molecule
FucP arabinose_Ext arabinose
Name: arabinose_Ext -> arabinose
Description: Transport of arabinose_Ext through a bacterial membrane, leading to the presence of arabinose inside the cell.
Type: transport
Pathway Components: arabinose_Ext - FucP -> arabinose
Components:
Function Name Type
catalyzer FucP protein
product arabinose simple_molecule
reactant arabinose_Ext simple_molecule
FucP galactose_Ext galactose
Name: galactose_Ext -> galactose
Description: Transport of galactose_Ext through a bacterial membrane, leading to the presence of galactose inside the cell.
Type: transport
Pathway Components: galactose_Ext - FucP -> galactose
Components:
Function Name Type
catalyzer FucP protein
product galactose simple_molecule
reactant galactose_Ext simple_molecule
fucPIKUR_mRNA FucI
Name: fucPIKUR_mRNA -> FucI
Description: Translation of FucI
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucI
Components:
Function Name Type
product FucI protein
reactant fucPIKUR_mRNA RNA
FucI α-L-fucose fuculose
Name: α-L-fucose -> fuculose
Description: Reaction transforming α-L-fucose into fuculose
Type: state transition
Pathway Components: α-L-fucose - FucI -> fuculose
Components:
Function Name Type
reactant α-L-fucose simple_molecule
catalyzer FucI protein
product fuculose simple_molecule
FucI arabinopyranose ribulose
Name: arabinopyranose -> ribulose
Description: Reaction transforming arabinopyranose into ribulose
Type: state transition
Pathway Components: arabinopyranose - FucI -> ribulose
Components:
Function Name Type
catalyzer FucI protein
reactant arabinopyranose simple_molecule
product ribulose simple_molecule
fucPIKUR_mRNA FucK
Name: fucPIKUR_mRNA -> FucK
Description: Translation of FucK
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucK
Components:
Function Name Type
product FucK protein
reactant fucPIKUR_mRNA RNA
FucK fuculose fuculose-1-P
Name: fuculose -> fuculose-1-P
Description: Reaction transforming fuculose into fuculose-1-P
Type: state transition
Pathway Components: fuculose - FucK -> fuculose-1-P
Components:
Function Name Type
catalyzer FucK protein
reactant fuculose simple_molecule
product fuculose-1-P simple_molecule
FucK ribulose ribulose-1-P
Name: ribulose -> ribulose-1-P
Description: Reaction transforming ribulose into ribulose-1-P
Type: state transition
Pathway Components: ribulose - FucK -> ribulose-1-P
Components:
Function Name Type
catalyzer FucK protein
reactant ribulose simple_molecule
product ribulose-1-P simple_molecule
fucPIKUR_mRNA FucU
Name: fucPIKUR_mRNA -> FucU
Description: Translation of FucU
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucU
Components:
Function Name Type
product FucU protein
reactant fucPIKUR_mRNA RNA
FucU α-L-fucose beta-L-fucose
Name: α-L-fucose -> beta-L-fucose
Description: Reaction transforming α-L-fucose into beta-L-fucose
Type: state transition
Pathway Components: α-L-fucose - FucU -> beta-L-fucose
Components:
Function Name Type
reactant α-L-fucose simple_molecule
catalyzer FucU protein
product beta-L-fucose simple_molecule
fucPIKUR_mRNA FucR
Name: fucPIKUR_mRNA -> FucR
Description: Translation of FucR
Type: translation
Pathway Components: fucPIKUR_mRNA -> FucR
Components:
Function Name Type
product FucR protein
reactant fucPIKUR_mRNA RNA
fucAO_mRNA FucA
Name: fucAO_mRNA -> FucA
Description: Translation of FucA
Type: translation
Pathway Components: fucAO_mRNA -> FucA
Components:
Function Name Type
product FucA protein
reactant fucAO_mRNA RNA
FucA fuculose-1-P lactaldehyde + DHAP
Name: fuculose-1-P -> lactaldehyde + DHAP
Description: Reaction transforming fuculose-1-P into lactaldehyde, DHAP
Type: state transition
Pathway Components: fuculose-1-P - FucA -> lactaldehyde + DHAP
Components:
Function Name Type
product DHAP simple_molecule
catalyzer FucA protein
reactant fuculose-1-P simple_molecule
product lactaldehyde simple_molecule
FucA ribulose-1-P glycoaldehyde + DHAP
Name: ribulose-1-P -> glycoaldehyde + DHAP
Description: Reaction transforming ribulose-1-P into glycoaldehyde, DHAP
Type: state transition
Pathway Components: ribulose-1-P - FucA -> glycoaldehyde + DHAP
Components:
Function Name Type
product DHAP simple_molecule
catalyzer FucA protein
product glycoaldehyde simple_molecule
reactant ribulose-1-P simple_molecule
fucAO_mRNA FucO
Name: fucAO_mRNA -> FucO
Description: Translation of FucO
Type: translation
Pathway Components: fucAO_mRNA -> FucO
Components:
Function Name Type
product FucO protein
reactant fucAO_mRNA RNA
FucO glycol glycoaldehyde
Name: glycol -> glycoaldehyde
Description: Reaction transforming glycol into glycoaldehyde
Type: state transition
Pathway Components: glycol - FucO -> glycoaldehyde
Components:
Function Name Type
catalyzer FucO protein
product glycoaldehyde simple_molecule
reactant glycol simple_molecule
1,2-propanediol FucO 1,2-propanediol lactaldehyde
Name: 1,2-propanediol -> lactaldehyde
Description: Reaction transforming 1,2-propanediol into lactaldehyde
Type: state transition
Pathway Components: 1,2-propanediol - FucO - 1,2-propanediol -> lactaldehyde
Components:
Function Name Type
inhibitor 1,2-propanediol simple_molecule
reactant 1,2-propanediol simple_molecule
catalyzer FucO protein
product lactaldehyde simple_molecule
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