RegulonDB RegulonDB

DsdC Genetic Sensory Response Unit in Escherichia coli K-12 genome


Gensor Unit Map          
DsdX serine dsdXA_mRNA DsdC This Gensor Unit is not yet available DsdA serine_Ext ammonium dsdC_mRNA dehydroalanine DsdC serine dsdXA dsdC pyruvate This Gensor Unit is not yet available


Gensor Unit       
Name: DsdC
Description: Molecular biology level
Detailed: In presence of serine, DsdC positively regulates the expression of genes invol required for serine transportation and catabolism and negatively regulates its own expression. Under this condition, DsdC is modified to DsdC-D-serine, binds its target sites preventing its own expression and enabling the expression of its regulated genes.
Less detailed: In the presence of serine, DsdC positively regulates the expression of genes needed for serine transportation and catabolism and negatively regulates its own expression.

Physiology level
Detailed: The presence of serine induces the expression of genes involved the assimilation of serine. Under this condition the genes necessary for serine uptake and degradation to pyruvate and ammonium, are expressed.
Less detailed: The presence of serine induces the expression of genes needful for the transport and degradation of serine to pyruvate and ammonium.
Classification:
Groups: Transcription
Carbohydrate transport and metabolism
Amino acid transport and metabolism
Gene Ontology Terms (GO): biological_process GO:0046416 - D-amino acid metabolic process
GO:0036088 - D-serine catabolic process
GO:0070178 - D-serine metabolic process
GO:0042942 - D-serine transport
GO:0006865 - amino acid transport
GO:0006520 - cellular amino acid metabolic process
Read more >
cellular_component GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016021 - integral component of membrane
GO:0005887 - integral component of plasma membrane
GO:0016020 - membrane
GO:0005886 - plasma membrane
molecular_function GO:0008721 - D-serine ammonia-lyase activity
GO:0042945 - D-serine transmembrane transporter activity
GO:0003677 - DNA binding
GO:0003700 - DNA-binding transcription factor activity
GO:0015128 - gluconate transmembrane transporter activity
GO:0016836 - hydro-lyase activity
GO:0016829 - lyase activity
Read more >
Components:
  Function Name Type
  protein DsdA protein
  protein DsdC protein
  complex DsdC-serine complex
  protein DsdX protein
  simple_molecule ammonium simple_molecule
  simple_molecule dehydroalanine simple_molecule
  gene dsdA gene
  RNA dsdA_mRNA RNA
  gene dsdC gene
  RNA dsdC_mRNA RNA
  gene dsdXA gene
  RNA dsdXA_mRNA RNA
  simple_molecule pyruvate simple_molecule
  simple_molecule serine simple_molecule
  simple_molecule serine_Ext simple_molecule


Reactions       
Showing 11 reactions
serine + DsdC DsdC-serine
Name: serine + DsdC -> DsdC-serine
Description: Reaction transforming serine, DsdC into DsdC-serine
Type: state transition
Pathway Components: serine + DsdC -> DsdC-serine
Components:
Function Name Type
reactant DsdC protein
product DsdC-serine complex
reactant serine simple_molecule
DsdC-serine dsdA dsdA_mRNA
Name: dsdA -> dsdA_mRNA
Description: Transcription of transcription unit dsdA. Reaction activation by DsdC-serine.
Type: transcription
Pathway Components: dsdA - DsdC-serine -> dsdA_mRNA
Components:
Function Name Type
activator DsdC-serine complex
reactant dsdA gene
product dsdA_mRNA RNA
DsdC-serine dsdXA dsdXA_mRNA
Name: dsdXA -> dsdXA_mRNA
Description: Transcription of transcription unit dsdXA. Reaction activation by DsdC-serine.
Type: transcription
Pathway Components: dsdXA - DsdC-serine -> dsdXA_mRNA
Components:
Function Name Type
activator DsdC-serine complex
reactant dsdXA gene
product dsdXA_mRNA RNA
DsdC-serine dsdC dsdC_mRNA
Name: dsdC -> dsdC_mRNA
Description: Transcription of transcription unit dsdC. Reaction inhibition by DsdC-serine.
Type: transcription
Pathway Components: dsdC - DsdC-serine -> dsdC_mRNA
Components:
Function Name Type
inhibitor DsdC-serine complex
reactant dsdC gene
product dsdC_mRNA RNA
dsdA_mRNA DsdA
Name: dsdA_mRNA -> DsdA
Description: Translation of DsdA
Type: translation
Pathway Components: dsdA_mRNA -> DsdA
Components:
Function Name Type
product DsdA protein
reactant dsdA_mRNA RNA
DsdA serine ammonium + pyruvate
Name: serine -> ammonium + pyruvate
Description: Reaction transforming serine into ammonium, pyruvate
Type: state transition
Pathway Components: serine - DsdA -> ammonium + pyruvate
Components:
Function Name Type
catalyzer DsdA protein
product ammonium simple_molecule
product pyruvate simple_molecule
reactant serine simple_molecule
DsdA serine dehydroalanine
Name: serine -> dehydroalanine
Description: Reaction transforming serine into dehydroalanine
Type: state transition
Pathway Components: serine - DsdA -> dehydroalanine
Components:
Function Name Type
catalyzer DsdA protein
product dehydroalanine simple_molecule
reactant serine simple_molecule
dsdC_mRNA DsdC
Name: dsdC_mRNA -> DsdC
Description: Translation of DsdC
Type: translation
Pathway Components: dsdC_mRNA -> DsdC
Components:
Function Name Type
product DsdC protein
reactant dsdC_mRNA RNA
dsdXA_mRNA DsdX
Name: dsdXA_mRNA -> DsdX
Description: Translation of DsdX
Type: translation
Pathway Components: dsdXA_mRNA -> DsdX
Components:
Function Name Type
product DsdX protein
reactant dsdXA_mRNA RNA
DsdX serine_Ext serine
Name: serine_Ext -> serine
Description: Transport of serine_Ext through a bacterial membrane, leading to the presence of serine inside the cell.
Type: transport
Pathway Components: serine_Ext - DsdX -> serine
Components:
Function Name Type
catalyzer DsdX protein
product serine simple_molecule
reactant serine_Ext simple_molecule
dsdXA_mRNA DsdA
Name: dsdXA_mRNA -> DsdA
Description: Translation of DsdA
Type: translation
Pathway Components: dsdXA_mRNA -> DsdA
Components:
Function Name Type
product DsdA protein
reactant dsdXA_mRNA RNA
R1 R2 R3 R4 R5 R6 R7 R8 R9 R10 R11



RegulonDB